Mounjaro vs Wegovy: Which Weight Loss Injection is Right for You?

Comparing Mounjaro and Wegovy

With the increasing popularity of weight loss injections, many people are comparing Wegovy vs Mounjaro to find the best solution for their needs. Two of the most talked-about treatments are Mounjaro and Wegovy. Both are prescription injections designed to aid in weight loss, but they work in slightly different ways and offer different benefits. If you’re considering medical weight management, it’s essential to understand how these treatments compare, and which one may be right for you.

Mounjaro, also known as tirzepatide, was originally developed to treat type 2 diabetes. However, due to its powerful effects on weight loss, it has gained popularity as a treatment for obesity. Wegovy, containing semaglutide, was specifically designed and approved for weight management. Both medications belong to a class of drugs called GLP-1 receptor agonists, but Mounjaro also acts on another receptor, GIP, which may contribute to greater weight loss.

How Do Mounjaro and Wegovy Work?

Wegovy works by mimicking a natural hormone called GLP-1, which helps regulate appetite and food intake. By slowing digestion and promoting a feeling of fullness, it can lead to significant weight loss when combined with diet and exercise. Patients using Wegovy inject the medication once a week, gradually increasing the dose over time. Find out more here: What is Wegovy 

Mounjaro also works on the GLP-1 receptor, but it has an added benefit—it mimics another hormone called GIP, which may enhance its ability to regulate appetite and insulin levels. This dual-action mechanism is believed to contribute to greater weight loss compared to Wegovy. Like Wegovy, Mounjaro is administered as a once-weekly injection, with dosing gradually increasing. Find out more here: What is Mounjaro 

Effectiveness of Mounjaro vs Wegovy

Clinical trials have compared the effectiveness of both medications for weight loss. The STEP 1 trial found that individuals using Wegovy lost an average of 15% of their body weight over a 68-week period. In contrast, the SURMOUNT-1 trial showed that Mounjaro users lost up to 22.5% of their body weight in 72 weeks, making it one of the most effective weight loss medications available.

Read the clinical study comparing Mounjaro and Wegovy here.

A more recent study published in JAMA confirmed these findings, highlighting that tirzepatide (Mounjaro) led to greater weight reduction than semaglutide (Wegovy).

Want to read more? View the study here.

Side Effects and Considerations

Both Wegovy and Mounjaro have similar side effects, as they work in comparable ways. The most common side effects include nausea, diarrhoea, constipation, and fatigue. These side effects are typically mild and decrease as the body adjusts to the medication. However, there are also rare but serious risks, such as pancreatitis and gallbladder issues, so it’s important to take these medications under medical supervision.

Click here to read more on Wegovy’s safety profile.

Some patients report that Mounjaro may have slightly fewer gastrointestinal side effects due to its dual-hormone action, but individual experiences vary. Anyone considering either medication should discuss potential side effects with their doctor.

Read the Clinical trials on Semaglutide for obesity and Tirzepatide for obesity here.

Cost

In terms of cost, both medications are prescription-only and can be purchased privately or through some healthcare providers. The price varies based on location and provider. Book an appointment with one of our GMC-registered doctors to discuss options.

Which Weight Loss Injection is Best for You?

Choosing between Mounjaro and Wegovy depends on your personal weight loss goals, medical history, and response to treatment. Wegovy is a NICE and MHRA-approved   weight loss treatment, making it a well-established option for those struggling with obesity. Mounjaro, while newer for weight loss, has shown higher weight reduction in clinical trials, making it a promising alternative for those looking for maximum results.

Before making a decision, it’s important to consult with a healthcare professional to discuss which medication is best suited to your needs. If you’re ready to start your weight loss journey, book a consultation today to discuss your options.